Plasticity of Circuits and Synapses

Synaptic integration and plasticity in hippocampal area CA3.
Plasticity in developing and adult neocortex.
Theoretical investigations of the impact of neural variability on sensory processing.
Cellular and circuitry mechanisms underlying pathological neural plasticity
Neuroimaging and cognitive studies of age and health.
Functional consequences of altered connectivity in schizophrenia; the early secretory pathway's role in neurodevelopment and synaptogenesis
Neural circuits in the basal ganglia involved in motor control and disease
Neurophysiology of basal ganglia system related to psychiatric disorders.
Synaptic computation and neuromodulation in catecholaminergic neurons
Cellular and circuitry mechanisms underlying drug addiction and sleep regulation of reward.
Regulation of GABAergic inhibition in development and mental disorders
Biophysics, pharmacology, and regulation of glutamate receptors.
Development and plasticity of inhibitory circuits.
Functional imaging methods and biophysics.
Development, plasticity and pain processing in sensory neurons and in the spinal dorsal horn.
Regulation and modulation of presynaptic ion channels and transmitter release in healthy and diseased synapses.
Adaption, learning, and plasticity in simulated neural networks.
Contributions of cortical microcircuit properties to information processing and coding in the olfactory system.
Motor control in humans.
The goal of our research is to functionally dissect the neural circuits that underlie pain and itch.
Theoretical and computational modeling of dynamics in neuronal networks.
Ultrastructure and the chemical nature of the tripartite synapse
Sensory physiology of the cerebral cortex.
Behavioral, biochemical, and physiological analysis of learning and memory.
Cellular mechanisms for learning and memory and their role in auditory processing.
Vestibular influences on autonomic control and navigation.