EducationPhD, University of Ottawa (2005)
How is it that smells can evoke such strong emotional memories? For many people, an unexpected whiff of a familiar scent transports the mind to memories of a cherished event, place or person. For others, odor-triggered recall can evoke traumatizing memories. My lab studies the neural circuits and mechanisms that underlie the encoding of olfactory information in the cortex. The overarching goal of my research is to understand how stable sensory representations are formed, maintained, and conversely, how they are retrained or diminished when no longer useful or pathological.
Most of my research has been driven by the quest to understand the relationship between synaptic dynamics and spike activity. Currently, we are investigating the role of inhibition in regulating the spatial profiles of neural activity as well as gating long-term synaptic plasticity and assembly formation during odor guided behavior. While many of the interneuron classes in piriform cortex have been identified, the specific roles interneuron types play in odor related activity and learning are unknown. Moreover, despite their popularity in other sensory cortices, the inhibitory circuits that regulate inhibition and potentially disinhibit pyramidal cells have not been identified in olfactory cortex. We capitalize on a variety of genetic tools, namely optogenetics, chemogenetics and TRAP (targeted recombination in active populations), which allow a detailed dissection of neural circuits and analysis of synaptic properties following odor-guided behavior. Our aim is to determine the microcircuit motifs that underlie sensory representation in the brain.
Kumar, A.L., Oswald, A.M., Urban, N.N., and Doiron, B. Shaping neural correlation through balanced synaptic inputs. PLoS Computational Biology. 7(12):e1002305, 2011.
Oswald, A.M., and Reyes, A.D. Development of inhibitory timescales in auditory cortex. Cerebral Cortex 21: 1351-1361, 2011.
Oswald, A.M.*, Doiron, B.*, Rinzel, J., and Reyes, A.D. Spatial profile and differential recruitment of GABAB modulate oscillatory activity in auditory cortex. J. Neuroscience. 29(33):10321-34, 2009.
Oswald, A.M., and Reyes, A.D. Maturation of the intrinsic and synaptic properties of L2/3 pyramidal neurons in mouse auditory cortex. J. Neurophysiology, 99:2998-3008, 2008.