Anthony E. Kline, PhD

Professor, Physical Medicine & Rehabilitation, Critical Care Medicine, Psychology, and Center for Neuroscience

Contact

Children’s Hospital of Pittsburgh, John G. Rangos Research Center – Room 6126
412-692-7092
klineae@upmc.edu
Website >

Education

PhD, University of Colorado at Boulder (1998)

Focus

Therapeutic strategies and mechanisms for experimental traumatic brain injury

Research Summary

Dr. Kline’s research includes neurobehavioral recovery and learning after experimental traumatic brain injury (TBI). Therapeutic strategies that include pharmacotherapy and environmental enrichment are utilized alone or in combination to restore function and/or attenuate TBI-induced deficits. Another interest is the evaluation of pharmacological agents that may hinder the recovery process after TBI (e.g., antipsychotics). The long-term goals of the laboratory are to develop therapies that facilitate functional recovery after TBI and to elucidate potential mechanisms for the observed effects. Additionally, the evaluation of therapies shown to benefit outcome in adult models of TBI are being investigated in pediatric models. Dr. Kline’s research is funded by the NIH. 

Dr. Kline is an Associate Director of Rehabilitation Research at the Safar Center for Resuscitation Research.  His laboratory is in the Rangos Research Center at Children's Hospital where ample collaboration exists between brain experts from the Departments of Physical Medicine & Rehabilitation, Neurological Surgery, and Critical Care Medicine. This wealth of knowledge, which includes, but is not limited to, numerous behavioral assessments as well as a variety of molecular and immunocytochemistry techniques, is available to graduate students whose interests are consistent with the overall goals of the laboratory.

Summer Undergraduate Research Program

Yes

Publications

 

Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE. Found in translation: understanding the biology and behavior of traumatic brain injury. Neurosci Biobehav Revs., 58:123-146, 2015.

Kline AE, Leary JB, Radabaugh HL, Cheng JP, Bondi CO. Combination therapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: is more better? Prog Neurobiol., 142:45-67, 2016. 

Radabaugh HL, LaPorte MJ, Greene AM, Bondi CO, Lajud N, Kline AE. Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury.  Exp Neurol., 294:12-18, 2017.

Folweiler KA, Bondi CO, Ogunsanya EA, LaPorte MJ, Leary JB, Radabaugh HL, Monaco CM, Kline AE. Combining the antipsychotic drug haloperidol and environmental enrichment after traumatic brain injury is a double-edged sword. J Neurotrauma, 34:451-458, 2017.

de la Tremblaye PB, O’Neil DA, LaPorte MJ, Cheng JP, Beitchman JA, Thomas TC, Bondi CO, Kline AE. Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation. Neurosci Biobehav Revs., 85:160-175, 2018.  

Lajud N, Díaz-Chávez A, Radabaugh HL, Cheng JP, Rojo-Soto G, Valdéz-Alarcón JJ, Bondi CO, Kline AE. Delayed and abbreviated environmental enrichment after brain trauma promotes motor and cognitive recovery that is not contingent on increased neurogenesis. J Neurotrauma, (In press, 2018).