Charles C. Horn, PhD

Associate Professor, Medicine


Hillman Cancer Center - Research Pavilion, 1.19d
F: 412-623-1119
Website >


PhD, Kansas State University (1996)


Neuromodulation of the vagus nerve in chronic diseases.

Research Summary

Dr. Horn’s primary research focus is the application of device technologies to modulate the communication between the peripheral and central nervous systems. The peripheral nervous system plays a critical role in the activation of highly aversive symptoms, such as nausea, emesis, and pain, and can contribute to the development of cancer, diabetes, and obesity. Currently, the lab is focused on the role of vagus nerve pathways in the treatment of cancer and gastrointestinal disease.

Summer Undergraduate Research Program



Horn CC, Ardell JL, & Fisher LE. Electroceutical targeting of the autonomic nervous system. Physiology. 2018 (in press).

Lothet EH, Shaw KM, Lu H, Zhuo J, Wang YT, Gu S, Stolz DB, Jansen ED, Horn CC, Chiel HJ, Jenkins MW. Selective inhibition of small-diameter axons using infrared light. Sci Rep. 2017 Jun 12;7(1):3275. > 

Rosenberg DM, Horn CC. Neurophysiological analytics for all! Free open-source software tools for documenting, analyzing, visualizing, and sharing using electronic notebooks. Journal of Neurophysiology. 2016. 116(2):252-62. >

Horn CC, Zirpel L, Sciullo M, and Rosenberg D. Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew. Neurogastroenterology and Motility. 2016. 28(8):1217-32. >

All Publications >

NIH funding (U18TR002205): Closed-loop neuroelectric control of emesis and gastric motility, a collaboration with Dr. Bill Yates (UPSOM, Dept. Otolaryngology) and Dr. Lee Fisher (UPSOM, Dept. Physical Medicine & Rehabilitation). 

UPMC funding: Bioelectronic device to control cancer, a collaboration with Dr. Gutian Xiao (UPSOM, Dept. Microbiology & Molecular Genetics), Dr. Lee Fisher, Dr. Gary Fedder (CMU), and Dr. Chris Bettinger (CMU)