ContactBiomedical Science Tower 3, Room 4074
EducationPhD, University of Pennsylvania (1972)
Dr. Strick's research focuses on three major issues: 1) the control of voluntary movement by the cerebral cortex, 2) the functional organization of the basal ganglia and cerebellum, and 3) unraveling the circuitry of the central nervous system.
In the past, the primary motor cortex (M1) was viewed as the main cortical area that projects to the spinal cord and generates movement. Other brain regions were thought to influence motor output solely by gaining access to M1. Experiments in Dr. Strick's laboratory have led to major modifications in this view. His results show that the frontal lobe contains at least six "premotor" areas. Each of these premotor areas projects directly to M1 and to the spinal cord. In fact, some of the neurons in the premotor areas are like neurons in M1 in having direct connections with spinal motoneurons that control muscles. Thus, the premotor areas have direct access to the spinal cord mechanisms responsible for volitional movement. Dr. Strick's laboratory is presently using modern neuroanatomical, physiological, and functional imaging techniques to determine how each of the cortical motor areas differentially contributes to the generation and control of voluntary movement.
His laboratory also is investigating the role of the premotor areas in the recovery of motor function that can occur following damage to M1 or its connections (as in spinal cord injury or strokes). Present evidence suggests that the premotor areas are important for the guidance of limb movements, the proper sequencing of motor tasks and the acquisition and retention of motor skills. Indeed, damage to the premotor areas in humans leads to a syndrome termed "apraxia" in which patients are unable to perform skilled motor tasks like dressing, shaving, and using tools.
Recently, Dr. Strick's laboratory also has provided new evidence that basal ganglia and cerebellar outputs are involved in a variety of nonmotor functions. His results suggest that concepts about the function of these subcortical centers should be broadened to include their involvement in cognitive processes such as working memory, rule-based learning, switching attention, visual perception, and the planning of future behavior. Furthermore, Dr. Strick's results support the growing evidence that dysfunction of the basal ganglia and/or cerebellum may be partly responsible for the symptoms of behavioral disorders such as schizophrenia, obsessive-compulsive disorder, attention deficit hyperactivity disorder, depression, and autism.
Levinthal, D.J. and Strick, P.L. The motor cortex communicates with the kidney. J Neurosci. May 9; 32(19): 6726-31, 2012.
RŸnger, D., Ashby, F.G., Picard, N. and Strick, P.L. Response-mode shifts during sequence learning of macaque monkeys. Psychol Res. Dec 9, 2011.
Cerebellar vermis is a target of projections from the motor areas in the cerebral cortex.Coffman KA, Dum RP, Strick PL. Proc Natl Acad Sci U S A. Sep 20;108(38):16068-73, 2011.
Bostan, A.C. and Strick, P.L. The cerebellum and basal ganglia are interconnected. Neuropsychol Rev. Sep;20(3): 261-70, 2010.
Bostan, A.C., Dum, R.P. and Strick, P.L. The basal ganglia communicate with the cerebellum.Proc Natl Acad Sci U S A. May 4;107(18): 8452-6, 2010.
Phillips, K.A., Sobieski,C,A,, Gilbert, V.R., Chiappini-Williamson, C., Sherwood, C.C. and Strick, P.L. The development of the basal ganglia in Capuchin monkeys (Cebus apella).Brain Res. May 6;1329: 82-8, 2010.
Dum, R.P., Levinthal, D.J. and Strick, P.L. The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. J Neurosci. Nov 11;29(45): 14223-35, 2009.