- PhD, Russian State Medical University, 2013
Education & Training
My laboratory is interested in whether targeting age-dependent metabolic reprogramming can extend healthspan and prevent neurodegeneration.
Metabolism plays a significant role in the regulation of aging and neurodegeneration at different levels. Studies in different model organisms revealed age- and neurodegeneration-dependent changes in various metabolic pathways. Although the flux via major metabolic pathways is relatively well studied in normal (young) cells, we have a very limited knowledge of how aging affects metabolic fluxes in old cells representing a significant knowledge gap. The central goal of my lab is to understand the mechanisms underlying age- and neurodegeneration-dependent metabolic reprogramming.
In the next few years, we will focus on answering these critical questions:
What is the fate of various important age-dependent metabolites? We previously applied 13C5-Methionine labeling in Drosophila to analyze how the activity of methionine metabolism flux is altered with aging or in a model relevant to AD. This demonstrated decreased activity of the methionine salvage pathway and methionine cycle in addition to a significant redirection of methionine into the transsulfuration pathway. We will expand our tracing analysis on other metabolites.
Parkhitko, A.A., Ramesh, D., Wang, L., Leshchiner, D., Filine, E., Binari, R., Olsen, A.L., Asara, J.M., Cracan, V., Rabinowitz, J.D., et al. (2020). Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. eLife 9.
Parkhitko, A.A., Wang, L., Filine, E., Jouandin, P., Leshchiner, D., Binari, R., Asara, J.M., Rabinowitz, J.D., and Perrimon, N. (2021). A genetic model of methionine restriction extends Drosophila health- and lifespan. Proceedings of the National Academy of Sciences of the United States of America 118.
Parkhitko AA, Jouandin P, Mohr SE, Perrimon N. Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species. Aging Cell. 2019 Dec;18(6):e13034. doi: 10.1111/acel.13034. Epub 2019 Aug 28. Review. PMID: 31460700
Parkhitko AA, Filine E, Mohr SE, Moskalev A, Perrimon N. Targeting metabolic pathways for extension of lifespan and healthspan across multiple species. Ageing Res Rev. 2020 Oct 5;101188. doi: 10.1016/j.arr.2020.101188. Review. PMID: 33031925
