The Translational and Computational Neuroimmunology research program lies at the intersection between data science and clinical and translational neuroimmunology. We investigate the drivers of individual differences in disease onset and progression and treatment response by harnessing multi-modal participant-derived samples and data and deploying a range of quantitative analytical methods. Our goal is to gain insights into the underlying disease process and to translate these findings into the clinical arena to improve the risk prediction, prevention, and management for people with chronic neuroimmunological and neurodegenerative diseases.