Kejie Yin, MD, PhD

  • Associate Professor, Neurology

Phone

412-383-6038

E-mail

yink2@upmc.edu

Fax

412-648-8081

Education & Training

MD, Yangzhou University Medical College (1983)
PhD, Fudan University Shanghai Medical College (1998)

Location

S-514 Biomedical Science Tower

Research Grants

Long non-coding RNAs and cerebral angiogenesis in ischemic stroke.

Research Interest Summary

Mechanisms of neurovascular damage and repair in ischemic and traumatic brain injury

Dr. Yin’s research interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural dysfunction after ischemic stroke and traumatic brain injury by using state-of-the-art cell biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal approaches. Currently, major ongoing research activities in Dr. Yin’s laboratory focus on investigating how non-coding RNAs (microRNAs, long non-coding RNAs) and Krüppel-like transcription factors regulate neurovascular pathophysiology (Blood-Brain Barrier disruption, Vascular and parenchymal inflammation, Angiogenesis, etc.), affect neurological outcomes, and modulate brain repair and functional recovery after ischemic stroke and traumatic brain injury. The long-term research goal of Dr. Yin’s laboratory is to discover novel molecular or pharmaceutical targets for the development of effective vaso-/neuro-protective or neurorestorative therapies against ischemic stroke and traumatic brain injury.

 

Yin KJ, Deng Z, Hamblin M, Huang HR, Xiang Y, Zhang JF, Wang YZ, Chen YE. PPARδ regulation of miR-15a in ischemia-induced vascular endothelial injury.  Journal of Neuroscience 2010; 30(18):6398-6408

Yin KJ, Deng Z, Hamblin M, Zhang JF, Chen YE. Vascular PPARδ protects against stroke-induced brain injury. Arteriosclerosis, Thrombosis, and Vascular Biology 2011; 31(3):574-81

Yin KJ, Olson K, Hamblin M, Zhang JF, Schwendeman SP, Chen YE. Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. Journal of Biological Chemistry 2012; 287(32): 27055-27064

Yin KJ, Fan YB, Hamblin M, Zhang JF, Li S, Hawse JR, Subramaniam M, Song CZ, Urrutia R, Lin JD, Chen YE. KLF11 mediates PPARgamma cerebrovascular protection in ischemic stroke. Brain 2013; 136:1274-1287

Yin KJ, Hamblin M, Zhang J, Chen YE. Non-coding RNAs and cerebrovascular endothelial pathophysiology in stroke. Neurochemistry International 2014; 77:9-16

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ.  Altered Long Non-coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia.  Experimental Neurology 2016; 277:162-70.

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered Long Non-coding RNA Transcriptomic Profiles in Brain Microvascular Endothelium after Cerebral Ischemia. Experimental Neurology 2016; 277:162-70.

Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ. Long Non-coding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 2017 February; 37(7):1797-1806.

Yang X, Tang X, Sun P, Shi Y, Liu K, Hassan SH, Stetler RA, Chen J, Yin KJ. MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 2017 Jul; 48(7):1941-1947.

Tang X, Liu K, Hamblin MH, Yin KJ.  Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic brain injury. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0556-9. [Epub ahead of print]

Yang X, Liu K, Hamblin MH, Steller A, Chen J, Yin KJ.  MicroRNA-15a/16-1 antagomir ameliorates ischemic brain injury in experimental stroke. Stroke 2017; 48(7):1941-1947

Zhang X, Tang X, Liu K, Hamblin MH, Yin KJ.  Long Non-coding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 2017; 37(7):1797-1806.

Zhang X, Hamblin MH, Yin KJ. The Long Noncoding RNA Malat1: Its physiological and pathophysiological functions. RNA Biology 2017 14 (12): 1705-1714

Tang X, Liu K, Hamblin MH, Xu Y, Yin KJ. Genetic deletion of Krüppel-Like Factor 11 aggravates ischemic brain injury. Molecular Neurobiology. 2018 Apr;55(4):2911-2921.

Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. MicroRNA-based therapeutics in central nervous system injuries. Journal of Cerebral Blood Flow and Metabolism 2018; 38(7): 1125-1148

Zhang X, Hamblin MH, Yin KJ. Non-coding RNAs and Stroke. Neuroscientist. 2019 Feb;25(1):22-26.

Ma F, Zhang X, Yin KJ. MicroRNAs in central nervous system diseases: a prospective role in regulating blood-brain barrier integrity. Experimental Neurology 2020 Jan; 323:113094. doi: 10.1016/j.expneurol.2019.113094.

Sun P, Zhang K, Hassan SH, Zhang X, Tang X, Pu H, Stetler RA, Chen J, Yin KJ. Endothelium-targeted deletion of microRNA-15a/16-1 promotes post-stroke angiogenesis and improves long-term neurological recovery. Circulation Research 2020;126(8):1040-1057.

Ma F, Sun P, Zhang X, Hamblin MH, Yin KJ. Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke. Science Signaling 2020 Apr 7;13 (626). pii: eaay5686.

Zhang X, Tang X, Ma F, Fan Y, Sun P, Zhu T, Zhang J, Hamblin MH, Chen YE, Yin KJ. Endothelium-targeted overexpression of Krüppel-like factor 11 protects blood-brain barrier function after ischemic brain injury. Brain Pathology 2020; 30 (4):746-765.

Zhang J, Sun P, Zhou C, Zhang X, Ma F, Xu Y, Hamblin MH, Yin KJ. Regulatory microRNAs and vascular cognitive impairment and dementia. CNS Neuroscience & Therapeutics 2020;26:1207-1218.

Zhang M, Hamblin MH, Yin KJ. Long non-coding RNAs mediate cerebral vascular pathologies after CNS injuries. Neurochemistry International. 2021 Jun 18:105102. doi: 10.1016/j.neuint.2021.105102. Online ahead of print.

Zhou C, Su M, Sun P, Ma F, Tang X, Yin KJ. Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury. Experimental Neurology 2021 Sep 6;113861. doi: 10.1016/j.expneurol.2021.113861. Online ahead of print.

Sun P, Ma F, Xu Y, Zhou C, Stetler RA, Yin KJ. Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway. Journal of Cerebral Blood Flow and Metabolism 2021; 41(10): 2725-2742.