Jami L. Saloman, PhD

  • Assistant Professor, Medicine and Neurobiology

Phone

412-383-5120

E-mail

jls354@pitt.edu

Personal Website

https://salomanlab.pitt.edu/

Education & Training

Phd, University of Maryland, Baltimore (2012)

Location

E1457 Starzl Biomedical Science Tower
200 Lothrop Stree

Research Interest Summary

Peripheral neurobiology, cancer neuroscience, pain

The research in the Saloman laboratory utilizes clinical research as well as in vitro and in vivo animal models to investigate the peripheral nervous system. The lab uses anatomical, behavioral, optogenetics, calcium imaging as well as traditional cellular and molecular techniques to elucidate how the peripheral nervous system regulates normal organ function, inflammation and pathological conditions, including pain and tumorigenesis.

Our lab is actively engaged in multi-disciplinary work focused on understanding neuro-immune-tumor interactions, particularly how neural regulation of the immune response shapes the incipient tumor microenvironment.

Representative Publications

Saleh M, Sharma K, Kalsi RS, Fusco J, Sehrawat A, Saloman JL, Guo P, Zhang T, Mohamed N, Wang Y, Prasadan K, Gittes G. Chemical Pancreatectomy: a potential treatment for chronic pancreatitis that preserves endocrine function. J Clin Invest. 2021 Feb 1;131(3):143301. PMID:33351784.

Blobner BM, Saloman JL, Shelton Ohlsen CA, Brand RE, Lafyatis R, Bottine R, Wijkstrom M, Zureikat AH, Lee KW, Singhi A, Whitcomb DC. Single-cell analyses of human pancreas: Characteristics of two populations of acinar cells in chronic pancreatitis. Am J Physiol-gastr l. 2021 Sept 15; PMID: 34523348.

Saloman JL*, Tang G, Stello KM, Hall KE, Wang X, AlKaade S, Banks PA, Brand RE, Conwell DL, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Lewis MD, Sherman S, Slivka A, Whitcomb DC, Yadav D, the NAPS Consortium. Serum Biomarkers for Chronic Pancreatitis Pain Patterns. Pancreatology. 2021 Sept 30;S1423-3903(21)00580-9. PMID: 34602367.

Saloman JL, Cohen JA, Kaplan DH. Intimate neuro-immune interactions: Breaking barriers between systems to make meaningful progress. Current Opinion in Neurobiology. 2019 Dec;6

Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 Jul;48(6):759-779. PMID: 31206467.

Saloman JL, Singhi AD, Hartman DJ, Normolle DP, Albers KM, Davis BM. Systemic depletion of nerve growth factors inhibits disease progression in a genetically engineered model of Pancreatic Ductal Adenocarcinoma. Pancreas 2018 Aug; 47(7):856-863. Pubmed PMID: 29975347.

Saloman JL, Scheff NN, Snyder LM, Ross SE, Gold MS, Davis BM. Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-independent Functional Changes in Sensory Neurons. J Neurosci. 2016 Oct 19; 36(42): 0769-10781. Pubmed PMID: 27798132.

Saloman JL, Albers KM, Hartmann DJ, Li D, Crawford HC, Muha EA, Rhim AD, Davis BM. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of tumorigenesis. PNAS. 2016 Mar 15; 113(11): 3078-3083. Pubmed PMID: 26929329.