- PhD, Emory University (2009)
Education & Training
A cornerstone of my research program is using postmortem human brain tissue to study the “organ of the disease.” My research program primarily focuses on schizophrenia, and we ask questions like: 1) What is the nature of glutamatergic and GABAergic synaptic dysfunction? 2) Do mitochondrial alterations contribute to cellular and synaptic dysfunction? 3) What molecular and synaptic alterations contribute to dopaminergic dysfunction in schizophrenia? 4) Are pathologies identified in schizophrenia unique or shared with other psychiatric disorders?
The laboratory employs a variety of molecular and imaging techniques, including volume electron microscopy (VEM), multi-label spinning disk confocal light microscopy, laser capture microdissection, in situ hybridization, and transcriptomic profiling to identify molecular, synaptic, organelle, cellular and neural circuit abnormalities that contribute to brain dysfunction underlying clinical symptoms.
Glausier JR (corresponding author), Enwright JF, Lewis DA. Cortical transcriptomic profiling reveals cellular and mitochondrial adaptive stress signatures that differ between schizophrenia and bipolar disorder. Schizophr Bull. 2025 Sep 24: sbaf147. PubMed PMID: 40990808.
Glausier JR (corresponding author), Maier M, Bouchet-Marquis C, Wu K, Banks-Tibbs T, Melchitzky D, Ning J, Lewis DA, Freyberg Z. Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex. iScience. 2025 May 26;28(7): 112747. PubMed PMID: 40585366.
Glausier JR. Neuronal synaptic communication and mitochondrial energetics in human health and disease. In: Tropea D, Giacometti E (Eds). Brain-Body Connections. Adv Exp Med Biol. 2025 v.1477. Springer, Cham. PubMed PMID: 40442385.
Hsieh C, Schmelzer T, Buck SA, Franks J, Hampton CM, Lewis DA, Marko M, Freyberg Z (Preprint) Cryo-FIB workflow for imaging brain tissue via in situ cryo-electron microscopy. BioRxiv 528064. Available from: https://doi.org/10.1101/2023.02.11.528064 *Designates equal contribution.
Glausier JR, Banks-Tibbs T, Ward C, Kozel J, Fu C, Fish KN, Lewis DA, Logan RW, Freyberg Z. Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain. Mol Psychiatry. 2025 Jul;30(7):3039-3054. PubMed PMID: 39875589.
https://www.ncbi.nlm.nih.gov/myncbi/jill.glausier.1/bibliography/public/
