- PhD, Fudan University Shanghai Medical College (1998)
- MD, Yangzhou University Medical College (1983)
Education & Training
Long non-coding RNAs and cerebral angiogenesis in ischemic stroke.
Dr. Yin’s research interest is to study the cellular & molecular mechanisms and therapeutic strategies of cerebrovascular and neural dysfunction after ischemic stroke and traumatic brain injury by using state-of-the-art cell biology, molecular biology, biochemistry, pharmacology, morphology, imaging, behavior and transgenic animal approaches. Currently, major ongoing research activities in Dr. Yin’s laboratory focus on investigating how non-coding RNAs (microRNAs, long non-coding RNAs) and Krüppel-like transcription factors regulate neurovascular pathophysiology (Blood-Brain Barrier disruption, Vascular and parenchymal inflammation, Angiogenesis, etc.), affect neurological outcomes, and modulate brain repair and functional recovery after ischemic stroke and traumatic brain injury. The long-term research goal of Dr. Yin’s laboratory is to discover novel molecular or pharmaceutical targets for the development of effective vaso-/neuro-protective or neurorestorative therapies against ischemic stroke and traumatic brain injury.
Zhang X, Tang X, Ma F, Fan Y, Sun P, Zhu T, Zhang J, Hamblin MH, Chen YE, Yin KJ. Endothelium-targeted overexpression of Krüppel-like factor 11 protects blood-brain barrier function after ischemic brain injury. Brain Pathology 2020; 30 (4):746-765.
Zhang J, Sun P, Zhou C, Zhang X, Ma F, Xu Y, Hamblin MH, Yin KJ. Regulatory microRNAs and vascular cognitive impairment and dementia. CNS Neuroscience & Therapeutics 2020;26:1207-1218.
Zhang M, Hamblin MH, Yin KJ. Long non-coding RNAs mediate cerebral vascular pathologies after CNS injuries. Neurochemistry International. 2021 Jun 18:105102. doi: 10.1016/j.neuint.2021.105102. Online ahead of print.
Zhou C, Su M, Sun P, Ma F, Tang X, Yin KJ. Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury. Experimental Neurology 2021 Sep 6;113861. doi: 10.1016/j.expneurol.2021.113861. Online ahead of print.
Sun P, Ma F, Xu Y, Zhou C, Stetler RA, Yin KJ. Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway. Journal of Cerebral Blood Flow and Metabolism 2021; 41(10): 2725-2742.
