Kenneth N. Fish, PhD

Title/Position
Assistant Professor, Psychiatry

    Education & Training

  • PhD, Oregon Health and Science University (1998)
Research Interests

Functional consequences of altered connectivity in schizophrenia; the early secretory pathway's role in neurodevelopment and synaptogenesis

Dr. Fish and his colleagues are interested in two different, but converging research areas: (1) identifying how key cells, potential pharmacological targets, involved in GABA neurotransmission are affected in schizophrenia; (2) defining the functional role of the early secretory pathway in neuronal polarity, development, and synaptogenesis. Studies utilize primary cells/tissue and advanced microscopy methodologies.

Research Concentration
Axonal Guidance and Synaptogenesis
Cortical Circuits
Neurodegeneration and Neurodegenerative Diseases
Neurotransmitter Receptors, Ion Channels and Membrane Transporters
Plasticity and Circuits and Synapses
Schizophrenia and Affective Disorders
Recent Publications

Georgiev D, Yoshihara T, Kawabata R, Matsubara T, Tsubomoto M, Minabe Y, Lewis DA, Hashimoto T: Cortical gene expression after a conditional knockout of 67 kDa glutamic acid decarboxylase in parvalbumin neurons. Schizophr Bull 42:992-1002, 2016. 

Volk DW, Sampson AR, Zhang Y, Edelson JR, Lewis DA: Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychol Med 46:2501-2512, 2016. 

Datta D, Arion D, Roman KM, Volk DW, Lewis DA: Altered expression of ARP2/3 complex signaling pathway genes in prefrontal layer 3 pyramidal cells in schizophrenia. Am J Psychiatry, ePub August 13, 2016. 

Chung W, Fish KN, Lewis DA: Pathological basis for deficient excitatory drive to cortical parvalbumin interneurons in schizophrenia. Am J Psychiatry, ePub July 22. 

Enwright JF, Sanapala S, Goflio A, Berry R, Fish KN, Lewis DA:  Reduced labeling of parvalbumin neurons and perineuronal nets in the dorsolateral prefrontal cortex of subjects with schizophrenia.  Neuropsychopharmacology, 41:2206-14, 2016. 

Rocco BR, Lewis DA, Fish KN: Markedly lower glutamic acid decarboxylase 67 protein levels in a subset of boutons in schizophrenia. Biol Psychiatry, 79:1006-1015, 2016.

Kimoto S, Glausier JR, Fish KN, Volk DW, Bazmi H, Arion D, Datta D, Lewis DA: Reciprocal alterations in regulator of G-protein signaling 4 and microRNA16 in schizophrenia. Schizophr Bull, ePub September 30, 2015. 

Chung W, Volk DW, Arion D, Zhang Y, Sampson AR, Lewis DA: Dysregulated ErbB4 splicing in schizophrenia: Selective effects on parvalbumin expression. Am J Psychiatry, 173:60-68, 2016. 

Fish, K.N., Sweet, R.A., Deo, A.J. and Lewis, D.A. An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections. Brain Res. 1240:62-72, 2008.

 

Fish, K.N. and Krucker, T. Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32:391-401, 2008.

Barr, A.M., Fish, K.N., Markou, A. and Honer, W. Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins. Euro J Neurosci. 27(10): 2568-2574, 2008.

Maclaurin, S.A., Krucker, T. and Fish, K.N. Hippocampal dendritic arbor growth in vitro: Regulation by reelin-disabled-1 signaling. Brain Res 1172:1-9, 2007.

Aridor, M., Guzik, A.K., Bielli, A. and Fish, K.N. Endoplasmic reticulum export site formation and function in dendrites. J Neurosci 24(15):3770-3776, 2004.