- MD, University of Pittsburgh, 2003
Education & Training
Central deficit in psychotic disorders is the disordered processing of cognitive tasks that results in impaired cognition that underlie the manifest symptoms and functional consequences such as poor social functions. Often neurobiology, discerned using fMRI data, often provide clues based on averaging over relatively long periods of time that does not inform functional neural circuits that dynamically change over several milliseconds. Characterizing the pattern of such dynamic changes in circuitry can provide useful markers for a better mechanistic understanding of the disease process, develop treatments, and track the treatment response. They are also used for improving diagnostic accuracy, clinical decision making, and identification of circuitry important at individual level. We use advanced statistical and mathematical modeling techniques to elucidate the above. Current interests are understanding the dynamics of multiplex neural circuitry using state-space model, latent state model, and AI-based predictive modeling. Another interest is to understand the resilience of neural circuitry as a basis of treatment response and clinical outcomes in person with psychotic disorders. The latter two are currently supported by federal grants. Ongoing developments are to leverage these findings to herald interventional neuroscience as a clinical and research discipline.
Theis N, Bahuguna J, Rubin JE, Muldoon B, Prasad KM* (2025) Energy of functional brain states correlates with cognition in adolescent-onset schizophrenia and healthy persons. Human Brain Mapping. Jan; 46(1):e70129. Doi:10.1002/hbm.70129. PMID: 39777939, PMCID: PMC11707705
Lewis MT, Theis N, Girish N, Prasad KM*. (2025) Determining the Atlas Correspondence of Desikan-Killiany-Tourville and Glasser MMPI Atlases across Magnetic Field Strengths. Journal of Neuroscience Methods. Jan: 181; DOI: 106771-106783
Lewis MT, Jiang W, Theis N, Cape JR, Prasad KM* (2024) Classification of psychosis spectrum disorders using graph convolutional networks using structurally constrained functional connectomes. Neural Networks. 181, 106771, DOI: 10.1016/j.neunet.2024.106771
Mitra AM, Prasad KM, Cape JR (2024) On inference for modularity statistics in structured networks, Journal of Computational and Graphical Statistics. 33(4), 1370-1382, DOI: 10.1080/10618600.2024.2336147
Lewis M, Santini T, Theis N, Muldoon B, Dash K, Keshavan MS, Prasad KM* Modular architecture and resilience of structural covariance network in first-episode antipsychotic-naive psychoses, Scientific Reports, 2023 May(12):13(1):7751. PMID: 37173346 PMCID: PMC10181992 DOI: 10.1038/s41598-023-34210-y
Theis N, Rubin J, Cape J, Iyengar S, Prasad KM* Threshold selection for Brain Connectomes. Brain Connectivity. 2023 13(7):383-393. doi: 10.1089/brain.2022.0082. Epub 2023 Jun 14. PMID: 37166374 PMCID: PMC10517318
Prasad KM*, Muldoon B, Theis N, Iyengar S, Keshavan M. Multipronged investigation of morphometry and connectivity of hippocampal network in relation to risk for psychosis using ultrahigh field MRI. Schizophrenia Research, 2023 Jun:256:88-97. doi: 10.1016/j.schres.2023.05.002. Epub 2023 May 15. PMID: 37196534
McGuigan BR, Santini T, Keshavan MS, Prasad KM* Gene expressions preferentially influence cortical thickness of human connectome project atlas parcellated regions in first-episode antipsychotic-naïve psychoses. Schizophrenia Bulletin Open. 2023 19;4(1): sgad019. doi: 10.1093/schizbullopen/sgad019. eCollection, PMID” 37621304
Prasad KM*, Gertler J, Tollefson S, Wood JA, Roalf D, Gur RC, Gur RE, Almasy L, Pogue-Geile MF, Nimgaonkar VL. Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families. Psychological Medicine, 2022, 52(5); 989-1000, EPub ahead of print 2020 Feb 6. doi: 10.1017/S0033291720002883. PMID: 32878667
Devanand DP, Wisniewski T, Razlighi Q, Qian M, Wei R, Andrews HA, Acosta EP, Bell KL, Pelton GH, Deliyannides D, Perrin AC, Caccappolo E, Gershon AA, Prasad KM, Kreisl WC, Mintz A, Huey ED (2025). Valacyclovir treatment of early symptomatic Alzheimer’s disease: The VALAD randomized clinical trial. JAMA, Dec 17:e2521738. DOI: 10.1001/jama.2025.21738. Online ahead of print. PMID: 41405855
Prasad KM*, Chowdari KV, D’Aiuto L, Iyengar S, Stanley JA, Nimgaonkar VL. Neuropil Contraction in relation to Complement C4 Gene Copy Numbers in Independent Cohorts of Adolescent-onset and Young Adult-onset Schizophrenia Patients – A Pilot Study. Translational Psychiatry. 2018 Jul 19;8(1):134. doi: 10.1038/s41398-018-0181-z. PMID: 300658868
Haszto CS, Stanley JA, Iyengar S, Prasad KM* Regionally Distinct Alterations in Membrane Phospholipid Metabolism in Schizophrenia: A Meta-analysis of Phosphorus Magnetic Resonance Spectroscopy Studies. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2020 5(3), 264-280. EPub ahead of print 2019 Oct 1 PMID: 31748123. PMCID: PMC7064428.
Devanand DP, Andrews HA, Kreisl WC, Razlighi Q, Gershon A, Stern Y, Mintz A, Wisnewski TR, Acosta E, Bell K, Pelton H, Deliyannides D, Prasad KM, Huey ED Antiviral therapy in Alzheimer’s Disease: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial, British Medical Journal (Open), 2020 10(2):e032112. PMID: 32034019
Keshavan MS, Eack SM, Prasad KM, Haller CS, Cho RY. Longitudinal functional brain imaging study in early course schizophrenia before and after cognitive enhancement therapy. Neuroimage 2017 May 1;151:55-64. doi: 10.1016/j.neuroimage.2016.11.060. Epub 2016 Nov 26. PMID: 27894892
D’Aiuto L*, Prasad KM*, Upton CH, Viggiano L, Milosevic J, Raimondi G, McClain L, Chowdari KV, Tischfield J, Sheldon M, Moore J, Yolken RH, Kinchington P, Nimgaonkar VL. Persistent infection with HSV-1 associated with changes in working memory, brain activation patterns and functional architecture of iPSC-derived neurons, Schizophrenia Bulletin, 2015 Jan;41(1):123-32. doi: 10.1093/schbul/sbu032. Epub 2014 Mar 12. PubMed PMID: 24622295; PubMed Central PMCID: PMC4266288 (*equally contributed to the manuscript)
