- PhD, University of Michigan (2017)
Education & Training
Molecular mechanisms underlying circadian rhythm disruptions in psychiatric and substance use disorders
Our research focuses on the molecular mechanisms underlying circadian rhythm disruptions in psychiatric and substance use disorders. We use a multi-omics approach in postmortem human brain tissue to identify alterations in molecular rhythms associated with conditions such as schizophrenia, major depressive disorder, and alcohol use disorder. We then use rodent models to determine the functional relevance of these rhythmic disruptions. Our ultimate goal is to deepen our understanding of the bidirectional relationship between circadian dysfunction and psychiatric illness and to identify novel therapeutic targets and treatment strategies.
Perez, M.S., Yin, R., Scott, M.R., Zong, W., Seney, M.L., Xue, X., Hildebrand, M.A., Shankar, V.G., Glausier, J.R., Lewis, D.A., Tseng, G.C., Ketchesin, K.D., and McClung, C.A. (2025). Sex and regional differences in gene expression across the striatum in psychosis. Translational Psychiatry, 15(1):192. DOI: 10.1038/s41398-025-03395-3. PMID: 40473621.
Jenkins, A.K., Ketchesin, K.D., Becker-Krail, D.D., and McClung, C.A. (2024). Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance for Psychiatric Disease. Biological Psychiatry, 96(12):909-918. DOI: 10.1016/j.biopsych.2024.05.007. PMID: 38735357.
Ketchesin, K.D., Becker-Krail, D.D., Xue, X., Wilson, R.S., Lam, T.T., Williams, K.R., Nairn, A.C., Tseng, G.C., and Logan, R.W. (2023). Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome. Journal of Proteome Research, 22(7):2377-2390. DOI: 10.1021/acs.jproteome.3c00126. PMID: 37311105.
Ketchesin, K.D., Zong, W., Hildebrand, M.A., Scott, M.R., Seney, M.L., Cahill, K.M., Shankar, V.G., Glausier, J.R., Lewis, D.A., Tseng, G.C., and McClung, C.A. (2023). Diurnal alterations in gene expression across striatal subregions in psychosis. Biological Psychiatry, 93(2):137-148. DOI: 10.1016/j.biopsych.2022.08.013. PMID: 36302706.
Becker-Krail, D.D., Ketchesin, K.D., Burns, J.N., Zong, W., Hildebrand, M.A., DePoy, L.M., Vadnie, C.A., Tseng, G.C., Logan, R.W., Huang, Y.H., and McClung, C.A. (2022). Astrocyte Molecular Clock Function in the Nucleus Accumbens is Important for Reward-Related Behavior. Biological Psychiatry, 92(1):68-80. DOI: 10.1016/j.biopsych.2022.02.007. PMID: 35461698.
Ketchesin, K.D., Zong, W., Hildebrand, M.A., Seney, M.L., Cahill, K.M., Scott, M.R., Shankar, V.G., Glausier, J.R., Lewis, D.A., Tseng, G.C., and McClung, C.A. (2021). Diurnal rhythms across the human dorsal and ventral striatum. Proceedings of the National Academy of Sciences, 118(2):e2016150118. DOI: 10.1073/pnas.2016150118. PMID: 33372142.
Ketchesin, K.D., Becker-Krail, D., and McClung, C.A. (2020). Mood-Related Central and Peripheral Clocks.European Journal of Neuroscience, 51(1): 326-345. DOI: 10.1111/ejn.14253. PMID: 30402924.
