Bilge E. Ozturk, Molly E. Johnson, Michael Kleyman, Serhan Turunc, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valerie L. Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D. Aguirre, Jose-Alain Sahel, David V. Schaffer, Andreas R. Pfenning, John G. Flannery, William A. Beltran, William R. Stauffer, Leah C. Byrne. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. eLife. 2021;10:e64175 DOI: 10.7554/eLife.64175
Zhouhuan Xi, Bilge E. Ozturk, Molly E. Johnson, William R Stauffer, Leah C. Byrne. Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explants. bioRxiv. Sept 27 2021. https://doi.org/10.1101/2021.09.27.461256.
Gemayel M, Byrne LC, Ciulla T, Sahel JA. Delivery of Genetic Information: Viral Vector and Nonviral Vector Gene Therapies. Int Ophthalmol Clin. 2021 Jul 1;61(3):35-57. doi: 10.1097/IIO.0000000000000360.
Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. JCI Insight. 2020 Apr 9;. doi: 10.1172/jci.insight.135112. https://insight.jci.org/articles/view/135112.
Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Res. 2016 Feb;26(2):238-55.
Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015 May 7;161(4):817-32.
Xue Y, Shen SQ, Jui J, Rupp AC, Byrne LC, Hattar S, Flannery JG, Corbo JC, Kefalov VJ. CRALBP supports the mammalian retinal visual cycle and cone vision. J Clin Invest. 2015 Feb;125(2):727-38.
Byrne LC, Lee T, Flannery JG, Dalkara D. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Mol Ther. 2015 Feb;23(2):290-6.
Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration. J Clin Invest. 2015 Jan;1 25(1):105-16.
Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Ther. 2014 Jun;21(6):585-92.
Day TP/Byrne LC, Schaffer DV, Flannery JG. Advances in AAV Vector Development for Gene Therapy in the Retina. Adv Exp Med Biol. 2014;801:687-93.
Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. PLoS One. 2013 Sep 27;8(9):e76075.
Dalkara D/Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Sci Transl Med. 2013 Jun 12;5(189):189ra76.
Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the retina through systemic administration of tyrosine mutated AAV9. Gene Ther. 2012 Feb;19(2):176-81.