- PhD, University of Pittsburgh (2019)
Education & Training
Dr. Eagle's work is multifocal with diverse interests in improving clinical outcomes for patients with TBI and/or exposure to repetitive head impacts including sport-related concussion, hospitalized populations and long-term sequelae. Current foci of Dr. Eagle's work include: 1. how systemic health at the time of injury impacts TBI recovery and long-term health; 2. Multifactorial relationships between bodily systems, exposure to TBI/repetitive head impacts, and long-term sequelae; 3. Improving prognostic models for patients with severe TBI; and 4. Leveraging implementation science to improve uptake of new technologies for the assessment and management of TBI into clinical practice.
Eagle SR, Yue JK, Shanahan RM, Shim J, Puccio AM, Okonkwo DO. A Propensity-Matched Comparison of Capacity for Functional Recovery by 24 Months Post-traumatic Brain Injury in Patients Who Died After Withdrawal of Life-Sustaining Therapy. Neurosurgery. 2026 Jan 13. doi: 10.1227/neu.0000000000003879. Epub ahead of print. PMID: 41552866.
Okonkwo DO, Collins MW, Kontos AP, Lopez O, Mountz JM, Wisniewski SR, Edelman KL, Benso S, Holland C, Beers SR, Soose RJ, Harrison T, Mucha A, Puccio A, Mancinelli M, Borrasso A, Rosario BL, Laymon C, Lopresti B, Minhas D, Agarwal V, Ostop S, Khalifa O, Berman S, Snitz B, Eagle SR. Pittsburgh Brain Health Initiative (BHI): protocol and methods for an observational study of cognitive function in former professional football players and controls. BMJ Open. 2025 Dec 24;15(12):e108735. doi: 10.1136/bmjopen-2025-108735. PMID: 41448702; PMCID: PMC12742072.
Eagle SR, Kershaw E. Clinical Outcomes in the Patient With Traumatic Brain Injury and Comorbid Obesity: A Scoping Review. Obes Rev. 2026 Mar;27(3):e70040. doi: 10.1111/obr.70040. Epub 2025 Nov 18. PMID: 41254930.
Eagle SR, Puccio A, Svirsky S, Mountz J, Laymon C, Borasso A, Henry L, Okonkwo DO. Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy Controls. Neurotrauma Rep. 2025 Jul 2;6(1):560-568. doi: 10.1089/neur.2025.0052. PMID: 40630648; PMCID: PMC12235121.
Eagle SR, Huber D, McCrea M, Okonkwo DO, Harezlak J, McAllister T, Pasquina P, Broglio S, Meier TB; CARE Consortium Investigators. Effect of Obese Body Mass Index on Clinical Outcomes and Inflammatory Blood Biomarkers following Sport-Related Concussion in Collegiate Athletes and Military Cadets: Findings from the NCAA-DoD CARE Consortium. Sports Med. 2025 Nov;55(11):2891-2903. doi: 10.1007/s40279-025-02257-8. Epub 2025 Jun 25. PMID: 40560505.
Eagle SR, Temkin N, Barber JK, McCrea M, Giacino JT, Okonkwo D, Manley GT, Nelson L; TRACK-TBI Investigators. Association of Subacute Mild Traumatic Brain Injury Symptoms With Long-Term Persistent Symptoms, Functional Limitations, and Quality of Life. Neurology. 2025 Apr 22;104(8):e213427. doi: 10.1212/WNL.0000000000213427. Epub 2025 Apr 1. PMID: 40168631; PMCID: PMC11966525.
Eagle SR, Svirsky SE, Puccio AM, Borrasso A, Edelman K, Beers S, Agoston D, Soose R, Collins M, Kontos A, Schneider W, Okonkwo DO. Predictive Blood Biomarkers of Targeted Intervention for Chronic Mental Health Symptoms following Traumatic Brain Injury. J Neurotrauma. 2025 Mar;42(5-6):e454-e460. doi: 10.1089/neu.2024.0245. Epub 2024 Oct 9. PMID: 39323312; PMCID: PMC11971543.
Eagle SR, Grashow R, DiGregorio H, Terry DP, Baggish A, Weisskopf MG, Okonkwo DO, Zafonte R. Interaction of Medical Conditions and Football Exposures Associated with Premortem Chronic Traumatic Encephalopathy Diagnosis in Former Professional American Football Players. Sports Med. 2024 Mar;54(3):743-752. doi: 10.1007/s40279-023-01942-w. Epub 2023 Oct 6. PMID: 37798551.
