- PhD, Carnegie Mellon University, Aug. 6, 1997
Education & Training
MuSIC 4 MIND:
Multi-Systems Imaging Characterization for Mitochondrial Involvement in The overarching goal for the “MuSIC 4 MIND” lab is to understand how brain functions, the placenta-brain axis, and the heart-brain connection by launching novel sensitive imaging methodology: (A) to understand etiology and reveal what cannot be seen, understood, or appreciated with the current clinical practice by developing more sensitive advance imaging methods; (B) to facilitate early detection and diagnosis before irreversible tissue damage occurs to allow timely intervention; and (C) to establish non-invasive imaging-based surrogate biomarkers for guiding therapeutic development and efficacy. The current research programs entail leveraging the novel systems imaging methods with MRI and molecular imaging with PET and SPECT to guide molecular investigation of mitochondrial involvement in epilepsy, traumatic brain injury (TBI), post-traumatic epileptogenesis, fetal alcohol syndrome, in utero exposure on neurodevelopment, childhood-onset epileptic encephalopathy in rodent models.
Wu YL, Christodoulou AG, Beumer JH, Rigatti LH, Fisher R, Ross M, Watkins S, Cortes DRE, Ruck C, Manzoor S, Wyman SK, Stapleton MC, Goetzman E, Bharathi S, Wipf P, Wang H, Tan T, Christner SM, Guo J, Lo CWY, Epperly MW, Greenberger JS. Mitigation of Fetal Radiation Injury from Mid-Gestation Total-body Irradiation by Maternal Administration of Mitochondrial-Targeted GS-Nitroxide JP4-039. Radiation research. 2024. Epub 2024/07/30. doi: 10.1667/rade-24-00095.1. PubMed PMID: 39074819
Reynolds WT, Votava-Smith JK, Gabriel G, Lee VK, Rajagopalan V, Wu Y, Liu X, Yagi H, Slabicki R, Gibbs B, et al. Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease. Journal of Clinical Medicine. 2024; 13(19):5772. https://doi.org/10.3390/jcm13195772
Cortes DRE, Stapleton MC, Schwab KE, West D, Coulson NW, O'Donnell MG, Christodoulou AG, Powers RW, Wu YL. Modeling normal mouse uterine contraction and placental perfusion with non- invasive longitudinal dynamic contrast enhancement MRI. PloS one. 2024;19(7):e0303957. Epub 2024/07/01. doi: 10.1371/journal.pone.0303957. PubMed PMID: 38950083; PMCID: PMC11216620.
Constantinesco NJ, Srikanth S, De Vito L, Moras C, Ramasubramanian V, Chinnappan B, Hartwick S, Schwab KE, Wu Y, Gopal R. STAT1 regulates neutrophil gelatinase B-associated lipocalin induction in influenza-induced myocarditis. Scientific reports. 2024;14(1):11124. Epub 2024/05/16. doi: 10.1038/s41598-024-61953-z. PubMed PMID: 38750107; PMCID: PMC11096373
Stapleton MC, Koch SP, Cortes DRE, Wyman S, Schwab KE, Mueller C, McKennan CG, Boehm-Sturm P, Wu YL (2023) Apolipoprotein-E (ApoE) Deficiency Leads to Brain Network Alteration Characterized by Diffusion MRI and Graph Theory. Frontiers in neuroscience. 2023, doi:10.3389/fnins.2023.1183312. PMID: 38075287; PMCID: PMC10702609.
Akinyele O, Munir A, Johnson MA, Perez MS, Gao Y, Foley JR, Wu Y, Murray-Stewart T, Casero RA, Jr., Bayir H, Kemaladewi DU. Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a mouse model of Snyder-Robinson syndrome. Disease models & mechanisms. 2024;17(6). Epub 2024/03/11. doi: 10.1242/dmm.050639. PubMed PMID: 38463005; PMCID: PMC11103582
Wang H, Lu J, Stevens T, Roberts A, Mandel J, Avula R, Ma B, Wu Y, Wang J, Land CV, Finkel T, Vockley JE, Airik M, Airik R, Muzumdar R, Gong Z, Torbenson MS, Prochownik EV. Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation. Cell Rep. 2023;42(8):112830. Epub 2023/07/23. doi: 10.1016/j.celrep.2023.112830. PubMed PMID: 37481724.
Chen Z, Stapleton MC, Xie Y, Li D, Wu YL, Christodoulou AG. Physics-informed deep learning for T2- deblurred superresolution turbo spin echo MRI. Magnetic resonance in medicine. 2023. Epub 2023/08/14. doi: 10.1002/mrm.29814. PubMed PMID: 37578085.
Zusman BE, Wu Y, Kochanek PM, Vagni VE, Janesko-Feldman K, Gerzanich V, Simard JM, Karahalios K, Mihaljevic S, Raikwar S, Rani A, Rulney J, Desai SM, Catapano J, Jha RM. Precision Effects of Glibenclamide on MRI Endophenotypes in Clinically Relevant Murine Traumatic Brain Injury. Crit Care Med. 2023;51(2):e45-e59. Epub 2023/01/21. doi: 10.1097/ccm.0000000000005749. PubMed PMID: 36661464; PMCID: PMC9848216
Shang P, Simpson JD, Taylor GM, Sutherland DM, Welsh OL, Aravamudhan P, Natividade RDS, Schwab K, Michel JJ, Poholek AC, Wu Y, Rajasundaram D, Koehler M, Alsteens D, Dermody TS. Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nature Commun. 2023;14(1):2615. Epub 2023/05/06. doi: 10.1038/s41467-023-38327-6. PubMed PMID: 37147336; PMCID: PMC10163058.
Cummings J, Wu YL, Dixon CE, Henchir J, Simard JM, Panigrahy A, Kochanek PM, Jha RM, Aneja RK. Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis. J Neuroinflammation. 2023;20(1):12. Epub 2023/01/22. doi: 10.1186/s12974-023-02692-2. PubMed PMID: 36681815; PMCID: PMC9862964.
Turan S, Chaillet JR, Stapleton MC, Wu YL. Genome Editing and Myocardial Development. Advances in experimental medicine and biology. 2023;1396:53-73. Epub 2022/12/02. doi: 10.1007/978-981-19- 5642-3_4. PubMed PMID: 36454459.
Golbourn BJ, Halbert ME, Halligan KE, Varadharajan S, Krug B, Mbah N, Kabir N, Stanton AJ, Locke A, Casillo S, Zhao Y, Sanders L, Cheney A, Mullett SJ, Mirhadi S, McCarl L, Chang Y-F, Wu YL, Gatesman TA, Cruz AF, Zapotocky M, Hu B, Kohanbash G, Wang X, Vartanian A, Moran M, Lieberman F, Amankulor NM, Wendell SG, Morozova O, Panigrahy A, Felker J, Bertrand KC, Kleinman C, Rich JN, Broniscer A, Lyssiotis C, Jabado N, Pollack IF, Mack SC and Agnihotri S. Loss of MAT2A and methionine dependency are indispensable for H3K27M mutant gliomas. Nature Cancer. 2022, May;3(5):629-648, PMID: 35422502, DOI: 10.1038/s43018-022-00348-3
Bharathi SS, Zhang BB, Paul E, Zhang Y, Schmidt AV, Fowler B, Wu Y, Tiemeyer M, Inamori KI, Inokuchi JI, Goetzman ES. GM3 synthase deficiency increases brain glucose metabolism in mice. Mol Genet Metab. 2022;137(4):342-8. Epub 2022/11/07. doi: 10.1016/j.ymgme.2022.10.006. PubMed PMID: 36335793.
Han L, Mich-Basso JD, Li Y, Ammanamanchi N, Xu J, Bargaje AP, Liu H, Wu L, Jeong JH, Franks J, Stolz DB, Wu YL, Rajasundaram D, Liu Y, Kühn B. Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts. Dev Cell. 2022;57(20):2397-411.e9. Epub 2022/10/26. doi: 10.1016/j.devcel.2022.09.017. PubMed PMID: 36283391; PMCID: PMC9614572.
Carew NT, Schmidt HM, Yuan S, Galley JC, Hall R, Altmann HM, Hahn SA, Miller MP, Wood KC, Gabris B, Stapleton MC, Hartwick S, Fazzari M, Wu YL, Trebak M, Kaufman BA, McTiernan CF, Schopfer FJ, Navas P, Thibodeau PH, McNamara DM, Salama G, Straub AC. Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death. J Clin Invest. 2022;132(18). Epub 2022/09/16. doi: 10.1172/jci147120. PubMed PMID: 36106636; PMCID: PMC9479700.
Teekakirikul P, Zhu W, Xu X, Young C, Tan T, Smith AM, Wang C, Peterson KA, Gabriel GC, Ho S, Sheng Y, Moreau de Bellaing A, Sonnenberg D, Lin H, Fotiou E, Tenin G, Wang MX, Wu YL, Feinstein T, Devine W, Gou H, Bais A, Zahid M, Wong TC, Ahmad F, Rynkiewcz M, Lehman WJ, Keavney B, Alastalo T-P, Freckmann ML, Orwig K, Murray S, Ware SM, Zhao H, Feingold B and Lo CW. Genetic Resiliency Associated With Dominant Lethal TPM1 Mutation Causing Atrial Septal Defect With High Heritability. Cell Reports Medcine. 2022; Feb 15;3(2):100501. PMID: 35243414. PMCID: PMC8861813 , DOI: 10.1016/j.xcrm.2021.100501
Gabriel GC, Devine WA, Redel BK, Whitworth KM, Samuel M, Spate LD, Cecil RF, Prather RS, Wu YL, Wells KD, Lo CW. Profiling development of abdominal organs in the pig. Sci. Rep. 2022;12(1):16245. Epub 2022/09/29. doi: 10.1038/s41598-022-19960-5. PubMed PMID: 36171243; PMCID: PMC9519580.
Wu YL. Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration. Methods Mol Biol. 2021;2158:81-106. doi: 10.1007/978-1-0716-0668-1_8. PubMed PMID: 32857368.
Chiba T, Cerqueira DM, Li Y, Bodnar AJ, Mukherjee E, Pfister K, Phua YL, Shaikh K, Sanders BT, Hemker SL, Pagano PJ, Wu YL, Ho J, Sims-Lucas S. Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2021;32(3):553-62. Epub 2021/01/31. doi: 10.1681/asn.2020050717. PubMed PMID: 33514560.
Feldman KS, Kim E, Czachowski MJ, Wu Y, Lo CW, Zahid M. Differential effect of anesthetics on mucociliary clearance in vivo in mice. Scientific Reports. 2021;11(1):4896. doi: 10.1038/s41598-021- 84605-y. PMID: 33649513
Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S and Lo CW. Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021;2(3):100037. PMID: 34888534, PMCID: PMC8653519 , DOI: 10.1016/j.xhgg.2021.100037
Chen A, Jiang Y, Li Z, Wu L, Santiago U, Zou H, Cai C, Sharma V, Guan Y, McCarl LH, Ma J, Wu YL, Michel J, Shi Y, Konnikova L, Amankulor NM, Zinn PO, Kohanbash G, Agnihotri S, Lu S, Lu X, Sun D, Gittes GK, Wang Q, Xiao X, Yimlamai D, Pollack IF, Camacho CJ and Hu B. Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. J Clin Invest. 2021;131. PMID: 34228644, PMCID: PMC8363281 , DOI: 10.1172/JCI147552
Gabriel GC, Devine W, Redel BK, Whitworth KM, Samuel M, Spate LD, Cecil RF, Prather RS, Wu Y, Wells KD and Lo CW. Cardiovascular Development and Congenital Heart Disease Modeling in the Pig. Journal of the American Heart Association. 2021;10:e021631. PMID: 34219463, PMCID: PMC8483476 , DOI: 10.1161/JAHA.121.021631
Sinsheimer A, Mohsen AW, Bloom K, Karunanidhi A, Bharathi S, Wu YL, Schiff M, Wang Y, Goetzman ES, Ghaloul-Gonzalez L and Vockley J. Development and characterization of a mouse model for Acad9 deficiency. Mol Genet Metab. 2021;134:156-163. PMID: 34556413, PMCID: PMC8588265, DOI: 10.1016/j.ymgme.2021.09.002
Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, Shiva S, Hilaire CS, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF and Gladwin MT. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation. 2021;144:615-637. PMID: 34157861, PMCID: PMC8384699, DOI: 10.1161/CIRCULATIONAHA.121.053889
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska- Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayir H, Kagan VE. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nature Chem Biol. 2020;16(3):278-90. Epub 2020/02/23. doi: 10.1038/s41589-019-0462-8. PMID: 32080625. PMCID: PMC7233108 .
Rutledge C, Cater G, McMahon B, Guo L, Nouraie SM, Wu Y, Villanueva F, Kaufman BA. Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction. Cardiovasc Ultrasound. 2020 Mar 12;18(1):9. doi: 10.1186/s12947-020-00191-5. PubMed PMID: 32164714; PubMed Central PMCID: PMC7068892.
Han L, Choudhury S, Mich-Basso JD, Ammanamanchi N, Ganapathy B, Suresh S, Khaladkar M, Singh J, Maehr R, Zuppo DA, Kim J, Eberwine JH, Wyman SK, Wu YL, Kühn B. Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Dev Cell. 2020;53(1):42- 59.e11. Epub 2020/02/29. doi: 10.1016/j.devcel.2020.01.030. PubMed PMID: 32109383.
Koppes EA, Redel BK, Johnson MA, Skvorak KJ, Ghaloul-Gonzalez L, Yates ME, Lewis DW, Gollin SM, Wu Y, Christ SE, Yerle M, Leshinski A, Spate LD, Benne JA, Murphy SL, Samuel MS, Walters EM, Hansen SA, Wells KD, Lichter-Konecki U, Wagner RA, Newsome JT, Dobrowolski SF, Vockley J, Prather RS, Nicholls RD. A porcine model of phenylketonuria generated by CRISPR/Cas 9 genome editing. [Print]. JCI Insight; 2020 October. PMID: 33055427, PMCID: PMC7605535
Airik M, Schüler M, McCourt B, Weiss AC, Herdman N, Lüdtke TH, Widmeier E, Stolz DB, Nejak- Bowen KN, Yimlamai D, Wu YL, Kispert A, Airik R, Hildebrandt F. Loss of Anks6 leads to YAP deficiency and liver abnormalities. Hum Mol Genet. 2020 Nov 4;29(18):3064-3080. doi: 10.1093/hmg/ddaa197. PubMed PMID: 32886109.
Wu YL. Cardiac MRI Assessment of Mouse Myocardial Infarction and Regeneration. Methods Mol Biol. 2021;2158:81-106. doi: 10.1007/978-1-0716-0668-1_8. PubMed PMID: 32857368.
Chiba T, Cerqueira DM, Li Y, Bodnar AJ, Mukherjee E, Pfister K, Phua YL, Shaikh K, Sanders BT, Hemker SL, Pagano PJ, Wu YL, Ho J, Sims-Lucas S. Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2021;32(3):553-62. Epub 2021/01/31. doi: 10.1681/asn.2020050717. PubMed PMID: 33514560.
Feldman KS, Kim E, Czachowski MJ, Wu Y, Lo CW, Zahid M. Differential effect of anesthetics on mucociliary clearance in vivo in mice. Scientific Reports. 2021;11(1):4896. doi: 10.1038/s41598-021- 84605-y. PMID: 33649513
Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S and Lo CW. Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021;2(3):100037. PMID: 34888534, PMCID: PMC8653519 , DOI: 10.1016/j.xhgg.2021.100037
Chen A, Jiang Y, Li Z, Wu L, Santiago U, Zou H, Cai C, Sharma V, Guan Y, McCarl LH, Ma J, Wu YL, Michel J, Shi Y, Konnikova L, Amankulor NM, Zinn PO, Kohanbash G, Agnihotri S, Lu S, Lu X, Sun D,
Gittes GK, Wang Q, Xiao X, Yimlamai D, Pollack IF, Camacho CJ and Hu B. Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma. J Clin Invest. 2021;131. PMID: 34228644, PMCID: PMC8363281 , DOI: 10.1172/JCI147552
Gabriel GC, Devine W, Redel BK, Whitworth KM, Samuel M, Spate LD, Cecil RF, Prather RS, Wu Y, Wells KD and Lo CW. Cardiovascular Development and Congenital Heart Disease Modeling in the Pig. Journal of the American Heart Association. 2021;10:e021631. PMID: 34219463, PMCID: PMC8483476 , DOI: 10.1161/JAHA.121.021631
Sinsheimer A, Mohsen AW, Bloom K, Karunanidhi A, Bharathi S, Wu YL, Schiff M, Wang Y, Goetzman ES, Ghaloul-Gonzalez L and Vockley J. Development and characterization of a mouse model for Acad9 deficiency. Mol Genet Metab. 2021;134:156-163. PMID: 34556413, PMCID: PMC8588265, DOI: 10.1016/j.ymgme.2021.09.002
Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, Shiva S, Hilaire CS, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF and Gladwin MT. Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction. Circulation. 2021;144:615-637. PMID: 34157861, PMCID: PMC8384699, DOI: 10.1161/CIRCULATIONAHA.121.053889
Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T, 3rd, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK. Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis. Shock. 2019. Epub 2019/09/13. doi: 10.1097/shk.0000000000001446. PubMed PMID: 31513049.
Ling X, Latoche JD, Choy CJ, Kurland BF, Laymon CM, Wu Y, Salamacha N, Shen D, Geruntho JJ, Rigatti LH, Windish HP, Langton-Webster B, Berkman CE, Anderson CJ. Preclinical Dosimetry, Imaging, and Targeted Radionuclide Therapy Studies of Lu-177-Labeled Albumin- Binding, PSMA-Targeted CTT1403. Molecular Imaging and Biology 2019. Epub 2019/07/20. doi: 10.1007/s11307-019-01404-8. PubMed PMID: 31321650.c
Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar- Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Mugica M, Steinhauser ML, Kuhn B. Control of cytokinesis by beta-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019;11(513). Epub 2019/10/11. doi: 10.1126/scitranslmed.aaw6419. PubMed PMID: 31597755.
Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedon JC, Shapiro SD, Kolls JK, Campfield BT. Follistatin-like 1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2019. Epub 2019/12/14. doi: 10.1164/rccm.201905-0973OC. PubMed PMID: 31834999.
Wu YL, Lo CW. Diverse application of MRI for mouse phenotyping. Birth Defects Res. 2017 Jun 1;109(10):758-770. PubMed PMID: 28544650.
Liu X, Kim AJ, Reynolds W, Wu Y, Lo CW. Phenotyping cardiac and structural birth defects in fetal and newborn mice. Birth Defects Res. 2017 Jun 1;109(10):778-790. PubMed PMID: 28544620; PubMed Central PMCID: PMC5499535.
Yagi H, Liu X, Gabriel GC, Wu Y, Peterson K, Murray SA, Aronow BJ, Martin LJ, Benson DW, Lo CW. The Genetic Landscape of Hypoplastic Left Heart Syndrome. Pediatric Cardiology. 2018. Epub 2018/03/24. doi: 10.1007/s00246-018-1861-4. PubMed PMID: 29569026.
Zahid M, Feldman K, Garcia-Borrero G, Feinstein T, Pogodzinski N, Xu X, Yurko R, Czachowski M, Wu Y, Mason N, Lo C; Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio- Distribution, Imaging Application, and Mechanism of Transduction", Biomolecules. 2018 Nov 14;8(4). PMID: 30441852; PMCID: PMC6315548
Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA Jr, Tsang M, Martin LJ, Benson DW, Aronow BJ, Lo CW. The complex genetics of hypoplastic left heart syndrome. Nature Genetics. 2017 Jul;49(7):1152- 1159. PubMed PMID: 28530678
Yeh FC, Liu L, Hitchens TK, Wu YL. Mapping immune cell infiltration using restricted diffusion MRI. Magn Reson Med. 2017 Feb;77(2):603-612. PubMed PMID: 26843524.
Wu YL, Liu L, Yeh F, Rosario BL, Ho C. MRI Investigation of New Approach to Improve the Recovery of Myocardial Ischemia Reperfusion Injury by Treatment with Intralipid. World Journal of Cardiovascular Diseases, 2016, 6:352-371.
Liu L, Tseng L, Ye Q, Wu YL, Bain DJ, Ho C. A New Method for Preparing Mesenchymal Stem Cells and Labeling with Ferumoxytol for Cell Tracking by MRI. Sci Rep. 2016 May 18;6:26271. PubMed PMID: 27188664; PubMed Central PMCID: PMC4870722.
Ye Q, Liu L, Wu YL, Yeh F, Li WF, Tseng L, Ho C. Intralipid®attenuates acute cardiac allograft rejection in relation topromoting CD4+CD25+Foxp3+regulatory T-cells and inhibiting toll- likereceptor 4 expression. Transplantation Reports. 2017;2:1-9. doi: http://dx.doi.org/10.1016/j.tpr.2017.05.001
Ganapathy B, Nandhagopal N, Polizzotti BD, Bennett D, Asan A, Wu Y, Kuhn B. Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. PloS One. 2016;11(5):e0155456. Epub 2016/05/14. doi: 10.1371/journal.pone.0155456. PubMed PMID: 27175488; PMCID: PMC4866786.
Pearce PS, Wu Y, Rapuano A, Kelly KM, de Lanerolle N, Pan JW. Metabolic injury in a variable rat model of post-status epilepticus. Epilepsia. 2016 Dec;57(12):1978-1986. PubMed PMID: 27943308; PubMed Central PMCID: PMC5215597
Wu Y, Pearce PS, Rapuano A, Hitchens TK, de Lanerolle NC, Pan JW. Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats. J Cereb Blood Flow Metab. 2015 Nov;35(11):1862-70. PubMed PMID: 26104287; PubMed Central PMCID: PMC4635243.
Christodoulou AG, Hitchens TK, Wu YL, Ho C, Liang ZP. Improved subspace estimation for low- rank model-based accelerated cardiac imaging. IEEE Trans Biomed Eng. 2014 Sep;61(9):2451-7. PMID:24801352; PMCID: PMC4190021
Yeh FC, Ye Q, Hitchens TK, Wu YL, Parwani AV, Ho C. Mapping stain distribution in pathology slides using whole slide imaging. J Pathol Inform. 2014;5(1):1. Epub 2014/03/29. doi: 10.4103/2153-3539.126140. PubMed PMID: 24672736; PMCID: PMC3952401
Wu YL, Ye Q, Eytan DF, Liu L, Rosario BL, Hitchens TK, Yeh FC, Rooijen van N, Ho C. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circulation Cardiovasc Imaging. 2013 Nov;6(6):965-73. PubMed PMID: 24097421; PubMed Central PMCID: PMC3886711.
Liu L, Hitchens TK, Ye Q, Wu Y, Barbe B, Prior DE, Li WF, Yeh FC, Foley LM, Bain DJ, Ho C. Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with intralipid. Biochim Biophys Acta. 2013;1830:3447-3453, PMID: 23396002, PMCID: PMC3640706
Liu L, Ye Q, Wu Y, Hsieh WY, Chen CL, Shen HH, Wang SJ, Zhang H, Hitchens TK, Ho C. Tracking t-cells in vivo with a new nano-sized mri contrast agent. Nanomedicine. 2012, Nov;8(8):1345-54, PMID: 22406186; PMCID: PMC3383940
Wu YL, Ye Q, Ho C. Cellular and Functional Imaging of Cardiac Transplant Rejection. Curr Cardiovasc Imaging Rep. 2011 Feb 1;4(1):50-62. PubMed PMID: 21359095; PubMed Central PMCID: PMC3045087.
Chen CL, Zhang H, Ye Q, Hsieh WY, Hitchens TK, Shen HH, Liu L, Wu YJ, Foley LM, Wang SJ, Ho C. A new nano-sized iron oxide particle with high sensitivity for cellular magnetic resonance imaging. Mol Imaging Biol. 2011;13:825-839, PMID: 20862612, PMCID: PMC3087837
Wu YL, Ye Q, Sato K, Foley LM, Hitchens TK, Ho C. Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance. JACC Cardiovasc Imaging. 2009 Jun;2(6):731-41. PubMed PMID: 19520344; PubMed Central PMCID: PMC2752220.
Ye Q, Wu YL, Foley LM, Hitchens TK, Eytan DF, Shirwan H, Ho C. Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation. 2008 Jul 8;118(2):149-56. PubMed PMID: 18591438; PubMed Central PMCID: PMC2613640.
Mills PH, Wu YJ, Ho C, Ahrens ET. Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging. 2008;26:618-628, PMID: 18450402, PMCID: PMC3200563
Chang HH, Moura JM, Wu YL, Ho C. Automatic detection of regional heart rejection in uspio- enhanced mri. IEEE Trans Med Imaging. 2008;27:1095-1106, PMID: 18672427, PMCID: PMC2562708
Wu YL, Ye Q, Foley LM, Hitchens TK, Sato K, Williams JB, Ho C. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1852-7. PubMed PMID: 16443687; PubMed Central PMCID: PMC1413627.
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Kanno S, Wu YJ, Lee PC, Billiar TR, Ho C. Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. Circulation. 2001;104(8):945-50. Epub 2001/08/22. doi: 10.1161/hc3401.093155. PubMed PMID: 11514384.
Kanno S, Wu YJ, Lee PC, Dodd SJ, Williams M, Griffith BP, Ho C. Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation. 2001;104:934-938, PMID: 11514382.
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